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These patients were investigated clinically,radiologically, intraoperatively,and/or histopathologically at the same institution,and the diagnostic evaluations did not reveal a definite cardiac or hematologic cause for the stroke.Large filling defects were noted on conventional carotid angiography in two of these patients;in the third patient,the histopathological changes were compatible with vasospasm.To our knowledge,these changes have not been previously documented in human arteries.We suggest that some brain infarcts among crack cocaine users may result from vasospasm of large arteries and secondary intravascular thrombosis. |
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